Endocrine Abstracts

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

Adrenocortical carcinoma are rare, highly vascular tumours with a generally poor prognosis. We have studied the use of the antiangiogenic drug, thalidomide (TH), in 6 patients with metastatic adrenocortical carcinoma (5 patients had adrenalectomy and one patient was inoperable#). The response to thalidomide treatment is summarized in the following Table. Assuming the residual/metastatic tumours to have a spheroidal form, the tumour volume (V) was calculated using the eq...

A previously fit and well 27 year old Ghanaian male was brought to hospital by his cousin due to new behavioural changes. The patient was described by his cousin as a normally reserved, self-sufficient man who had become a polar opposite ‘irritable’ personality that ‘spent extravagantly’. He repeatedly claimed to be ‘God’s protection’ and responded aggressively to visual hallucinations. This had resulted in social exclusion and loss of employ...

Aim: Role of Endocrine Specialist Nurse (ESN) in performing cannulated prolactin and subsequent impact on outpatient clinic activities.Introduction: Hyperprolactinemia is a common condition in endocrine clinical practice. It may occur in any sex, at any age and its prevalence and incidence depend on study population. The most common physiological causes of elevated prolactin are stress, lactation, pregnancy and exercise. Non-physiological causes include ...

This is a case of a 38-year-old lady with a past medical history of Ehlers Danlos Syndrome, functional neurological syndrome and unremarkable cardiac investigations for palpitations. She was referred by her general practitioner (GP) with episodic shaking, excessive sweating, recurrent hypo-and hyperglycaemia recorded by her own capillary blood glucose (CBG) meter, ranging from 1.9mmol/l to 19mmol/l. The episodes would mostly occur 1 to 3 times per week, usually in the afternoo...

We present a 70-year-old female who was initially referred to the endocrinology clinic for an assessment of her type 2 diabetes mellitus. She has a complex medical history including treated hypothyroidism, mastectomy for breast cancer and ongoing yearly surveillance for an excised benign lung lesion. On further questioning she acknowledged feeling generally unwell in the days prior to her appointment and had self-presented to the emergency department with undiagnosed hypertens...

Thyroid cancer is the most common endocrine malignancy with an increasing incidence globally predominantly due to the papillary thyroid carcinoma subtype. It is the 17th and 20th most common malignancy in females and males respectively. In 2018, Cancer Research UK reported 3865 new cases and 400 deaths. Mortality rates are predicted to continue to rise in the UK with an estimated rate of 1 per 100,000 deaths in 2035. We present a 42-year-old female who pr...

Background: The increased risk for fractures in type 2 diabetes mellitus despite higher bone density is unexplained. Trabecular bone score (TBS) is a novel texture index related to bone microarchitecture and it is independent of bone mineral density (BMD). The aim of this study was to investigate the relationship between TBS, BMD and body composition in patients with New-Onset Diabetes after transplantation (NODAT).Methods: In a cross-sectional study, TB...

Primary hypoparathyroidism is a rare condition. Contrary to other endocrine deficiencies treated with hormone replacement, recombinant parathyroid hormone (PTH) is not currently licensed for its treatment in Europe. Emerging evidence of efficacy and safety of recombinant PTH in treating resistant hypoparathyroidism will hopefully provide a new tool in managing this challenging condition.This is the case of a 45 year-old woman presenting with gradually wo...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of cardiovascular complications. It is, also, well known that diabetes confers a substantial burden of microvascular disease. Previous studies suggest a link between microvascular and macrovascular events in diabetes. However, just a few studies have investigated whether the presence of previous cardiovascular events is associated with microvascular disease in diabetes patients. So, this is th...